Abstract:
In human steroid sensitive tissue, progesterone receptors (PRs) and estrogen receptors (ERs) have been demonstrated
at the mRNA and/or protein levels by using molecular biology and immunohistochemistry techniques. Estrogen and
progesterone receptors are present both in endometrial hyperplasia and in neoplastic endometrium. The aim of the
present work was to compare the expression of ER and PR as prognostic biomarkers in human endometrial
adenocarcinoma versus benign tumors and normal endometrial tissues as well as their correlation with different
pathological and histological parameters. Immunohistochemical technique was used to examine the expression of ER
and PR in normal, benign as well as in endometrial adenocarcinoma. Present results showed higher expression of ER
and PR in endometrial adenocarcinoma comparing to normal and benign endometrial tissues.
Keywords: ER and PR prognostic marker.
