Immunohistochemical Expression of Fn14 and Cath-D as Prognostic Biological Markers and Compare with Histological Reaction in Invasive Human Breast Cancer

Abstract

Fibroblast growth factor-inducible-14 (Fn14) is a 14-kDa type I transmembrane receptor located on chromosome 16p13. Fn14 is a member of the tumor necrosis factor receptor super family that normally expressed in healthy tissues, but its expression is increased in injured tissue where it thought to play role in tissue remodeling. Cathepsin D (Cath D) is a soluble lysosomal aspartyl glycoprotease that can degrade the protein components of the matrix and free growth factors therein embedded, thus favoring tumor growth, invasion and angiogenesis. The aim of the present work was to investigate the expression of Fn14 and Cathepsin D as novel prognostic biomarkers in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues as well as their correlation with different pathological and histological parameters. Immunohistochemical technique was used to examine the expression of Fn14 and Cath-D in normal, benign as well as in IDC. Present results showed higher expression of Fn14 and Cath-D in IDC comparing to normal and benign breast tissues. Keywords: Fn14 and Cathepsin D prognostic marker