Abstract:
Colorectal Cancer (CRC) is among the most common types of
cancer in the world. Globally a steadily increasing proportion
of elderly people in the world result in approximately 16
million new cases of cancer by the year 2021. Regarding
treatment; Meloxicam was shown to prevent the initiation
of chemical-induced tumors, and considered as anticancer
agent by virtue of its anti-proliferative effect, capacity for cell
cycle arrest, and pro-apoptotic effects, also acted as free
radical scavenger, in particular superoxide anion oxidation
scavenge. The aim of the current study was to clarify much
important information on histopathology, histochemistry and
immunoassay of CEA tumor marker characteristics of 1,2
DMH- induced colon tumor in albino rat and its relationship
with the aberrant crypt mucosa as precursor in colon cancer
progression. The study was carried out on 60 male albino
rats, animals were divided into 5 groups; A: control group,
B: animals received S.C. injections of 20 mg 1,2 DMH/K
