Abstract:
Background: Assessment of cell proliferation through the evaluation of cyclin D1, AgNORs, and DNA content
provides a promising approach to the prognosis of breast cancer. Therefore, this work aimed to evaluate the
prognostic significance of AgNORs and DNA image cytometry, and their relation to cyclin D1 immunoreactivity
in breast cancer.
Subjects and methods: This study was carried out on 50 prospective biopsies taken from patients with breast
tumors. They were divided into control (10 cases) and benign (10 cases) as well as malignant (30 cases) groups.
Computer-assisted image analysis cytometry is applied to evaluate the count of positive reactions of AgNORs and
Description:
Journal of Medical and Life Science, 2020, Vol.2, No. 4, P.54 -68
