Abstract:
Schiff bases are versatile ligands, synthesized via condensation of primary amines with
carbonyl compounds. In this study, equimolar amounts of 4-imidazolecarboxaldehyde and
thiosemicarbazide were combined and the Schiff base 4-imidazolecarboxaldehyde
thiosemicarbazone was prepared as a new bidentate complexing agent. The synthesized
ligand was reacted with palladium (II) and platinum (II) ions yielding air-stable complexes.
For characterization purpose, infrared spectra, mass spectra, electronic spectra, thermal
analysis, proton nuclear magnetic resonance and 13-carbon nuclear magnetic resonance
spectra studies were carried out on the obtained complexes and ligand. The characterization
data showed that the ligand acts as a bidentate coordinate to the metal ions through
azomethine nitrogen and sulfur atoms. An in vitro antimicrobial investigation was also
carried out for the free ligand and its metal complexes against four bacteria; Bacillus cereus,
Staphylococcus aureus (Gram-positive), Escherichia coli and Salmonella typhimurium (Gram negative) and one Fungi; Candida albicans, to assess their antimicrobial properties by disc
diffusion technique. Antimicrobial activity of the prepared complexes showed higher
activity than the free l
