Synthesis, Characterization and Biological Activity of Himdazole 2-carboaldehyde Thiosemicarbazone and its Cd (II), Hg (II) and Zn (II) Complexes

Abstract

Equimolar amounts of Himdazole-2-carboaldehyde and thiosemicarbazide were combined together and Himdazole-2-carboaldehyde thiosemicarbazone was prepared. The synthesized lingad was reacted with Cd (II), Hg (II) and Zn (II) ions yielding stable color complexes. For quantification and characterization purpose, elemental analysis, molar conductivity, infrared spectra, electronic spectra, proton nuclear magnetic resonance spectra, and mass spectra were carried out. The magnetic moment was also used for characterization. The ligand of IR spectrum showed that thiosemicarbazone coordinates to the metal ions via sulfur and azomethine nitrogen atom. The measurements of magnetic moment for all complexes were found to be (0.00). In range of normal for octahedral geometry and indicated all complexes were diamagnetic. An in vitro antimicrobial have been tested against a number of bacteria and fungal strains for the free ligand and its metal complexes, to assess their antimicrobial properties by diffusion technique. The ligand and its complexes exhibit higher activity against bacteria and fungi in compared with standar